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Principal investigator:
Prof. Erez Levanon erez.levanon@biu.ac.il
Erez Levanon
CV:

Start date: 09/2010

Research description:

RNA editing, genomic plasticity, retro-elements, computational biology, DNA editing, primate evolution

Post-docs:
Dr. Nurit Gal-Mark gmnurit@gmail.com
Nurit Gal-Mark
CV:

Start date: 09/2010

Personal web site:
Research description:

Detection of RNA editing alterations in neuronal diseases

Dr. Nurit Paz-Yaacov nuritpaz@gmail.com
Nurit Paz-Yaacov
CV:

Start date: 01/2011

Research description:

Cancer plasticity

Ph.D. students:
Khen Khermesh kkhens@gmail.com
Khen Khermesh
CV:

Start date: 11/2011

Personal web site:
Research description:

My research is focused on the extent and nature of A-to-I RNA editing in the coding sequence of mammalian genes.

Personal statement: I’m also an exuberant soccer coach for kids.

1. Creating a validated and characterized catalog containing over 400 sites of human A-to-I RNA editing, which were found to be located within the coding sequence (CDS/UTRs/Introns) of mammalian genes. The RNA editing sites will be classified upon various parameters like the levels of RNA editing, the expression profile of RNA and on the detection of specific patterns of editing sites that are restricted to certain tissues.

2. From that catalog human of A-to-I RNA editing, a limited set of editing sites representing the most prominent and promising candidates will turn into a selected probe-set designed to first, interrogate the overall RNA editing blueprint of a given tissue, in addition to specifically detect the RNA editing patterns of selected genes. Our efforts will be focused upon RNA editing in biological samples obtained from brain regions of alder human subjects.

3. RNA editing is not a phenomenon restricted to humans, it is encompasses many species. Based on the human catalog as a primary source, we have also produced species specific probe-sets of A-to-I RNA editing candidates’ sites for Rat (Rattus norvegicus) and for Zebra fish (Danio rerio). Both species are highly suitable to genetic manipulation and are also exploited to the generation of elaborated aminal-models allowing us to connect RNA editing levels and sites to a defined phenotype.


Publications:

1). Ben-Efraim, I.; Kliger, Y.; Hermesh, C.; Shai, Y.; Membrane-induced step in the activation of sendai virus fusion protein. Journal of molecular biology. 28, 2, 609-625. 1999. Elsevier

2). Tiran, Z.; Oren, A.; Hermesh, C.; Rotman, G.; Levine, Z.; Amitai, H.; Handelsman, T.; Beiman, M.; Chen, A.; Landesman-Milo, D.; A novel recombinant soluble splice variant of Met is a potent antagonist of the hepatocyte growth factor/scatter factor-Met pathway. Clinical Cancer Research. 14, 14, 4612-4621. 2008. AACR

3). Hecht, I.; Rong, J.; Sampaio, A.L.F.; Hermesh, C.; Rutledge, C.; Shemesh, R.; Toporik, A.; Beiman, M.; Dassa, L.; Niv, H.; A novel peptide agonist of formyl-peptide receptor-like 1 (ALX) displays anti-inflammatory and cardioprotective effects. Journal of Pharmacology and Experimental Therapeutics. 328, 2, 426. 2009. ASPET

4). Shemesh, R.; Hermesh, C.; Toporik, A.; Levine, Z.; Novik, A.; Wool, A.; Kliger, Y.; Rosenberg, A.; Bathgate, R.A.D.; Cohen, Y.; Activation of Relaxin?Related Receptors by Short, Linear Peptides Derived from a Collagen-Containing Precursor. Annals of the New York Academy of Sciences. 1160, 1, 78-86. 2009. Wiley Online Library

5). Pini, A.; Shemesh, R.; Samuel, C.S.; Bathgate, R.A.D.; Zauberman, A.; Hermesh, C.; Wool, A.; Bani, D.; Rotman, G.; Prevention of Bleomycin-Induced Pulmonary Fibrosis by a Novel Antifibrotic Peptide with Relaxin-Like Activity. Journal of Pharmacology and Experimental Therapeutics. 335, 3, 589. 2010. ASPET

Moran Gal
CV:

Start date: 09/2010

Personal web site:
Research description:

Identifying causative mutations for human diseases using Genome Wide Capturing and Sequencing Technologies.

Working as a genetic counselor for several years, I have counseled many individuals and families with various hereditary diseases. Although our understanding of genetic basis of human diseases is continuously improving, there are still numerous individuals and families suffering from hereditary conditions, of which the causal genes have yet to be discovered.

Being intrigued by novel genome technologies and the computational challenges in genomic data analysis, made me join Levanon's lab at Bar-Ilan University.

My research projects are aiming at integrating my practical experience and knowledge in clinical genetics with the advanced technologies and bioinformatics tools that are used in our lab. E.g, we are using novel genomic capturing techniques to facilitate gene's discoveries in families with hereditary disorders.

Miri Danan miridanan@yahoo.com
Miri Danan
CV:

Start date: 03/2011

Research description:

Alternative splicing

Jasmine Jacob-Hirsch jasmine.jacob@sheba.health.gov.il
Jasmine Jacob-Hirsch
CV:

Start date: 09/2010

Personal web site:
Research description:

Head of Functional Genomic Unit at the Sheba Medical Center Cancer research center.

In my research I am searching for the link between the adaptive potential of somatic mutation driven by retrotransposonal insertion events.

Tumors onset and progression were shown to be related to high somatic mutations, part of those events is driven by Retrotransposons (LINE1 for example) insertions. Retrotransposons events (RE) were reported to occur during neuronal fetal differentiation stages.

We are investigating the functional connection between RE de novo insertions and acquired ability to adapt in the brain and in the tumor context.

Out of lab, I enjoy all the activities that come by being the proud mother of four children, a long distance runner and cyclist.

Hagit Porath hagit_br@hotmail.com
Hagit Porath
CV:

Start date: 05/2013

Personal web site:
Research description:

Computational identification of ultra-edited RNAs.

Binyamin Knisbacher binknis@gmail.com
Binyamin Knisbacher
CV:

Start date: 07/2011

Research description:

Computational identification of DNA editing.

Identification of DNA editing sites. APOBEC3 mammalian proteins are able to induce C-to-U mutations in retrotransposons during reverse transcription. This led to numerous apparent G-to-A mutations between extant retrotransposon copies that might have dramatically affected their evolution. We are working on computational identification and characterization of those sites in various genomes and are examining intra- and inter-genomic diversity of DNA editing rates and patterns.

Yishay Pinto yipinto@gmail.com
Yishay Pinto
CV:

Start date: 09/2014 Finished on:

Personal web site:
Research description:

Genome Hyperediting.

Orshay Gabay orshayg@gmail.com
Orshay Gabay
CV:

Start date: 09/2014 Finished on:

Personal web site:
Research description:

Genome Hyperediting.

M.Sc. students:
Ilana Sychikov ilana.sychikov@gmail.com
Ilana Sychikov
CV:

Start date: 09/2014 Finished on:

Personal web site:
Research description:

Genome Hyperediting.

Lea Dvir
CV:

Start date: 09/2014 Finished on:

Personal web site:
Research description:

Genome Hyperediting.

Stas Trock
CV:

Start date: 09/2014 Finished on:

Personal web site:
Research description:

Genome Hyperediting.

Administration:
Odelia Zilbert odelia.lab@gmail.com
Odelia Zilbert
CV:

Start date: 09/2014

Personal web site:
Research description:

Genomic capturing algorithms

Consults:
Dr. Michal Barak michal.barak@gmail.com
Michal Barak
CV:

Start date: 09/2010

Personal web site:
Research description:

Genomic capturing algorithms

Dr. Lily Bazak lilybzk@gmail.com
Lily Bazak
CV:

Start date: 09/2010

Research description:

Global Characterization of Alu Editing and its Impact on the Human Genome.

We assume that RNA editing is a much more common phenomenon, occurring in the human genome more frequently than has been shown up till now. The purpose of my research is to map RNA editing in Alu repeats.

In addition, the role of RNA editing in Alu repeats is still mostly unclear. Recent findings have provided evidence of its impact on the expression of genes through a variety of mechanisms. It is also known that RNA editing is most active in brain and is essential for cognitive brain function. In light of the newly acquired data, I will investigate the possible functions of the RNA editing in Alu elements.

Dr. Ami Haviv ami.haviv@gmail.com
Ami Haviv
CV:

Start date: 09/2010

Personal web site:
Research description:

Past members:
Gilad Finkelstein finkelg@gmail.com
Research description:

Multi genomic screen for occurrence of double-stranded RNAs

Anastasia Shapiro uni.anastasia@gmail.com
Anastasia Shapiro
CV:

Start date: 09/2010     Finished on: 5/2012

Personal web site:
Research description:

Undergraduate student project: DNA editing of retro elements.

Dr. Oliver Keller keller74@gmail.com
Oliver Keller
CV:

Start date: 09/2010 Finished on: 9/2012

Personal web site:
Research description:

Genome Hyperediting.

Shai Carmi
CV:

Start date: 09/2010     Finished on: 10/2011

Research description:

(i )   Identifying DNA editing sites. APOBEC3 mammalian proteins are able to induce C-to-U mutations in retrotransposons during reverse transcription. This led to numerous apparent G-to-A mutations between extant retrotransposon copies that might have dramatically affected their evolution. We are working on computational identification and characterization of those sites.

(ii)   Ultra RNA editing. Hyper-activity of the human ADAR1 protein occasionally leads to extreme A-to-I editing of RNAs with particularly stable double-stranded form. We developed a novel approach to identify those cases of “ultra-editing” and understand the biological conditions when they arise.

Hani Harel
CV:

Start date: 10/2010

Personal web site:
Research description:

Somatic Activity of Retrotransposons in Human.